Tapentadol is partly metabolized with the hepatic enzymes CYP2C9, CYP2C19, and CYP2D6 so it innately has interactions with medicine that boost or repress the action/expression of one or more of such enzymes, together with with substrates of those enzymes (due to Competitors with the enzyme); some enzyme mediators/substrates need dosing https://nigeli809rja0.webbuzzfeed.com/profile