Abstract Androgen receptor (AR) plays an important role in the progression of prostate cancer and has been targeted by castration or AR-antagonists. The emergence of castration-resistant prostate cancer (CRPC) after androgen deprivation therapy (ADT) is inevitable. However. it is not entirely clear how ADT fails or how it causes resistance. https://www.ngetikin.com/limited-value-Sapatilha-Infantil-Pampili-Bailarina-Laco-Duplo-Glitter-Prata-great-pick/