Environmental or self-antigens and homotypic interactions trigger BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other signals from the microenvironment and rising the activation of anti-apoptotic and proliferation pathways.31,32 Genomic experiments have discovered recurrent mutations in genes regulating tumor mobile-microenvironment interactions, ... https://eldert887izo5.goabroadblog.com/profile